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Squamous Cell Carcinoma

Sinonimi: SCC, Squamous cell carcinoma, Squamous cell cancer, Spinalioma, Epidermal carcinoma, Epidermoid carcinoma, Papillary carcinoma, Verrucous carcinoma, Non-melanoma skin carcinoma

What is it??

SCC is a kind of skin carcinoma which develops in the epidermis. By order of frequence, SCC is just behind BCC in skin. At an early stage, when it’s non invasive, it is completely curable. At a later stage, invasive stage, it presents with an ability to metastasize to surrounding tissues and internal organs.

SCC- non-invasive type

SCC-invasive type

SCC-invasive type

How does it develop??

Skin SCC develops from damage to the squamous keratinous cells that produce keratin. Genetic predisposition and skin damage from UV overexposure are the primary reasons for developing this type of skin carcinoma. Damage from UV radiation gets accumulated during life, it starts with first exposure to the Sun (from birth) and can eventually lead to development of squamous cell carcinoma, but to other types of skin carcinoma as well..

SCC – non-invasive type

Dermoscopy

Which are the first signs of skin SCC?

Appearance of a small pink freckle, or a lesion on the skin like a light or pink nodule, is often a first sign that can be noted. There are usually no symptoms at this stage. Exactly this nonspecific appearance and character at the early stage is the reason why early diagnostics can be done only on persons that undergo regular check ups, or when it’s accidentally discovered during an examination of some other lesion. However, if it continues to further develop, it grows on the outside and on the inside, presenting with first symptoms in the form of an itch.

Skin Sun damage, with the firs signs that indicate initial development of skin SCC

Is there some sex, age or body region specificity?

SCC is a carcinoma that more commonly appears in men than in women. Number of young people affected by it is increasing. Still, the probability of it occurring is greatest after the age of 50. It is usually present on sun-exposed regions of the skin: face, forehead, hands and back, but SCC can develop on any skin region, with specific places being: lower lip, ear lobe and vulva.

How dangerous is it?

Skin SCC is considered as a medium metastatic potential carcinoma. Non-invasive type of skin SCC rarely metastasizes, while the invasive type of skin SCC has a larger potential to metastasize. Diameter-wise, skin SCC with a diameter greater than 4mm has a greater chance of metastasizing than a smaller one.

Is it curable?

Skin SCC is completely curable in all cases when it’s diagnosed and treated in a timely manner.

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